Proof: The "Golden Rice Test" suspect cloud opened

On December 6th, the China Center for Disease Control and Prevention, the Zhejiang Provincial Academy of Medical Sciences and the Hunan Provincial Center for Disease Control and Prevention issued a joint survey on the “golden rice” incident, unveiling a three-month long “golden rice test”.

The party provided false information

In August 2012, Tufts University Tang Guangwen and others published in the American Journal of Clinical Nutrition that β-carotene and oil capsules in "Golden Rice" are also effective for children's vitamin A supplementation. Research papers have aroused public concern (see the September 5th edition of this report, “Questionnaires on the “Golden Rice Experiment”). The main authors of the thesis are Tang Guangwen of Tufts University, Hu Yuming of Hunan Provincial Center for Disease Control and Prevention, Yin Shian of the Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, and Wang Yin of Zhejiang Academy of Medical Sciences. The other three authors were Gerald Droll, Mitchell Grusac, and Robert Russell.

The Ministry of Health, Zhejiang Province and Hunan Province attached great importance to it and instructed the China Center for Disease Control and Prevention, the Zhejiang Academy of Medical Sciences and the Hunan Provincial Center for Disease Control and Prevention to conduct joint investigations.

To find out the exact facts, the China Center for Disease Control and Prevention dispatched personnel to the Tufts University and the National Institutes of Health (NIH) investigation. According to Tufts University regulations, the ethical review of a single pilot project should be reviewed every year. Any changes to the project content should be reviewed. In 2008, Tang Guangwen started his experiment in Hengnan County before the ethical review was completed. Tufts University is also investigating issues involving violations of ethics in the trial.

The investigation found that in July 2008, the relevant department was informed that Tufts University conducted information on “Golden Rice” trials in China and conducted inquiries and investigations. The parties lied that the research work had not yet been carried out, but actually the field work had already ended. . In this survey, YI Shi-an and Wang Yin provided false information and seriously interfered with and hindered the investigation.

When the project was implemented, Tang Guangwen, Yin Shi'an, and Wang Yin were responsible for the project. They never told the local authorities and project undertakers that they were conducting “golden rice” experiments; they deliberately used “rich” when signing informed consent with the parents of the students. The expression of "carotenoid rice" deliberately concealed the fact that "golden rice" was used.

U.S. Privately Bringing “Golden Rice” to China; 25 children each consume 60g, parents are not fully informed

In December 2002, the NIH Institute of Diabetes, Digestive Tract and Kidney Diseases in the United States approved and Tang Guangwen from the Tufts University hosted the “Child Carrots Vitamin A Equivalents in Plants” project. Yasi Shi is a member of the project application. The project aims to study the efficiency of absorption and conversion of carotenoids in spinach, golden rice (commonly known as "golden rice") and beta carotene capsules into vitamin A in children.

In September 2003, YI Shi-an signed the NIH project cooperation agreement with the Zhejiang Academy of Medical Sciences as part of the project's project manager in China. In August 2004, Tufts University and Zhejiang Academy of Medical Sciences signed a memorandum of cooperation and research agreement. The cooperation project leader is Tang Guangwen. The Chinese heads are Yin Shian and Wang Yin.

In 2008, the project was transferred to Hengnan County, Hunan Province, where it was combined with the domestic project “Efficiency of Carotenoids in Plants converted to Vitamin A in Children” carried out by YI Shi-an. The China Center for Disease Control and Nutrition and the Zhejiang Academy of Medical Sciences signed cooperation agreements with Hunan respectively, but they did not explicitly inform that the experiment will use genetically modified rice or "golden rice."

From May 20 to June 23, 2008, the trial with the "Golden Rice" test group was implemented at the Central Primary School in Jiangkou Town. The test subjects were 80 children and were randomly divided into 3 groups. One group of 25 children consumed 60 grams of “golden rice” per person on lunch on June 2. The rest of the day and other groups of children consumed locally sourced food. .

The “Golden Rice” rice was cooked by Tang Guangwen in the United States and was not reported to the relevant domestic authorities as required. It was brought into China on May 29, 2008. At lunch on June 2, Tang Guangwen and others mixed and heated the “golden rice” rice and white rice and distributed it to the children.

On May 22, 2008, the research group held an informed briefing for parents and guardians of students, but did not explain to the parents and guardians of the test that the experiment will use genetically modified “golden rice”. Informed consent was issued only on the last page. Parents or guardians of students signed the page and there was no mention of “golden rice” on this page.

On June 2, 2008, the Tufts University Ethics Review Committee approved the ethical approval of the NIH project's Chinese version of the informed consent. The project leader did not follow the rules, and the subject’s informed consent was conducted ahead of schedule on May 22. Tufts University's informed consent form for the study, approved in 2008, did not mention that the test material was "genetically modified rice," but it was simply called "golden rice."

In November 2003, the Ethical Review Committee of the Zhejiang Academy of Medical Sciences passed the ethical review of the NIH project in the United States. After the project site work was transferred to Hunan in 2008, the project leader did not apply for an ethical review again as required. According to the materials provided by YI Shi-an, Wang Yin secretly affixed the official seal and issued the English version “2003” to Tang Guangwen in the name of Zhejiang Medical Academy. The result of the annual ethical review is still valid".

The Chinese party was disciplined

According to the relevant regulations, YI Shi-an was dismissed from the directorship of the maternal and child nutrition division of the Nutritional Food Institute of the Chinese Center for Disease Control and Prevention. His technical title has been downgraded from grade II researcher to grade III. He is not allowed to conduct scientific research within three years, disqualify doctoral tutors, and revoke party functions. Wang Yin was dismissed from the position of director of the Nutrition and Food Hygiene Research Office of the Institute of Health Food, director of the Office of Toxicology at the Public Health Center, canceled the qualifications recommended by the second-degree researcher, and was disqualified from membership of the Academic Committee of the College and the membership of the College Ethics Committee. He must not participate in the title within three years; Promote the work of the jury and give the party a warning; Hu Yuming was revoked the post of Assistant Director and Section Chief of the Hunan Center for Disease Control and Prevention and given the party a warning.

The Chinese Center for Disease Control and Prevention, the Zhejiang Provincial Academy of Medical Sciences and the Hunan Provincial Center for Disease Control and Prevention expressed their apology for the adverse impact of the incident and will use this as a warning to further strengthen the supervision of scientific research projects, improve internal rules and regulations, and strengthen laws and regulations. , research integrity, professional ethics and medical ethics education.

Heng Nan conducts psychological counseling for test students

The newspaper Changsha, December 6 (reporter Yan Yan), after learning about the findings of the “Golden Rice” incident, established a working group in Hengnan County, Hunan Province, organized relevant experts to provide psychological counseling, and a group of psychological experts appointed by the Ministry of Health Has arrived in Hengnan and began to solve questions and counseling and psychological counseling for test students and parents. At the request of the parents of the test students, Heng Nan contacted the physical examination hospital for the students. Students can voluntarily perform medical examinations and receive corresponding subsidies. (Wang Junping coordinator: Shen Xiaogen)

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